Pinkus fibroepithelioma

What is it fibroepithelioma from Pinkus?

Pinkus fibroepithelioma, also known as Pinkus tumor and Pinkus epithelioma, is a premalignant fibroepithelial tumor first which was described by Hermann Pinkus in 1953 [1]. Originally classified as a rare variant of basal cell carcinoma (BCC), a evil one neoplasmhas since been controversially reclassified as a trichoblastoma, a benign neoplasm [2–4].

Clinically, Pinkus fibroepithelioma can resemble a variety of benign skin tumors that are not routinely removed [5].

Who gets Pinkus fibroepithelioma?

There are few reported cases and few epidemiological data for Pinkus fibroepithelioma. This may be due to its similarity to benign skin lesions, resulting in the rarity of its diagnosis. [6].

Pinkus fibroepithelioma is primarily diagnosed in fair-skinned women and is most often located in the lumbosacral region, although it can occur anywhere on the skin [5,7]. It usually develops between 40 and 60 years of age, although there have been pediatric case reports of its occurrence [8,9].

What causes Pinkus fibroepithelioma?

the Pathogenesis and genetic The basis of Pinkus fibroepithelioma is not yet fully understood. Although the mechanisms may be similar to the development of BCC, chronic Ultraviolet damage appears to be a minor factor in Pinkus fibroepithelioma, as these tumors do not commonly develop in areas that are routinely exposed to the sun. [3.5].

A previous study with mice showed that mutations at PTCH transmembrane regulator gene in the Hedgehog signaling pathway it may be involved in the development of Pinkus fibroepithelioma [10]. Further studies are required to determine PTCH Mutations also play a role in its development in humans. In addition, there have been reports of Pinkus fibroepithelioma arising at sites of the skin after radiotherapy, although a direct relationship has not yet been defined [11].

What are the clinical features of Pinkus fibroepithelioma?

Pinkus fibroepithelioma usually presents as a single erythematous or flesh-colored, dome-shaped papule or license plate. Big pedunculatedulcerated cysticand pleomorphic variants with different pigmentation Combinations have also been reported [5,7].

Unlike BCC, there have been no reports of spontaneous bleeding in Pinkus fibroepithelioma.

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What are the complications of Pinkus fibroepithelioma?

Pinkus fibroepithelioma is not known to cause additional complications or malignancy. It has rarely been associated with other malignancies, such as breast carcinoma, breast Paget disease, and gastrointestinal tumors. [12–14].

How is Pinkus fibroepithelioma diagnosed?


Although a clinical examination is unlikely to lead to a diagnosis of Pinkus fibroepithelioma, due to its similarity to benign lesions, dermoscopy may be useful in diagnosis [6]. The following dermoscopic patterns are seen in Pinkus fibroepithelioma. [3,6,15]:

  • Polymorphous ships with mainly fine trees and peripheral dotted glasses
  • White streaks under polarized dermoscopy (also called chrysalis / crystal structures) similar to BCC
  • Milia-like cysts and ulceration (these are reported but are not specific for Pinkus fibroepithelioma)
  • Gray-brown pigmentation and gray-blue spots (in pigmented Pinkus fibroepithelioma).

Skin biopsy

The Goldus Fibroepithelioma Gold Standard Diagnostic Test is a skin biopsy taken to histopathological exam. Pinkus fibroepithelioma is characterized by interconnected and branched strands of basaloid cells embedded in a loose, richly vascular fibrous stroma, extending from the epidermis down in the dermis [3,16].

Creator: L Woźniak and KW Zielinski via Wikimedia Commons.

Which is the differential diagnosis for Pinkus fibroepithelioma?

Pinkus fibroepithelioma is generally mistaken for the following benign skin lesions:

  • A skin tag - this normally has a narrower base and lacks erythema
  • A dermal melanocytic nevus - this is devoid of erythema and is rarely stalked
  • A lonely neurofibroma - they are generally more compressible and lack erythema
  • A seborrheic keratosis - this has a more waxy appearance or warty surface and rarely stalks
  • A hemangioma - this lacks pedunculation and has a more uniform and deep erythema.

What is the treatment for Pinkus fibroepithelioma?

The definitive treatment for Pinkus fibroepithelioma is surgical. excision with margins of 4 mm, as indicated for BCC [4]. Electrodesiccation and curettage or Mohs micrographic surgery may be considered in higher risk locations, such as the head and neck, or in large tumors [3,7].

Doctor current Treatments, such as imiquimod, are not effective for Pinkus fibroepithelioma despite their role in treating superficial BCC [6]. There is no paper to chemotherapy or radiation

What is the result for Pinkus fibroepithelioma?

Pinkus fibroepithelioma is generally considered to have a indolent of course without metastatic potential [7.8]. The death of the patient has never been reported. [17].